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anti etv5  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc anti etv5
    Anti Etv5, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti+etv5/ETV5+Rabbit+mAb/pm41791643-77-22-24
    Average 94 stars, based on 10 article reviews
    anti etv5 - by Bioz Stars, 2026-10
    94/100 stars

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    other:

    Article Title: ETV5 transcriptionally activates TGFβ1 and promotes cancer cell invasion and migration of NSCLC.
    Article Snippet: Non-small cell lung cancer (NSCLC), which mainly includes lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), consists 85% of lung cancer worldwide (Yang et al. 2022).. Despite tremendous efforts had been made in diagnosis and treatment of lung cancer, an estimated 1.7 million people die of lung cancer each year (Bray et al. 2018).. Moreover, lung cancer is a heterogeneous disease at the molecular level.

    Article Title: First Generation Tools for the Modeling of Capicua (CIC) - Family Fusion Oncoprotein-Driven Cancers
    Article Snippet: Antibodies and dilutions or concentrations used were: anti-HA clone C29F4 (Cell Signaling Technology 3724, 1:1000-1:5000), anti-HSP90 (Cell Signaling Technology 4874, 1:1000), anti-ETV5 clone E5G9V (Cell Signaling Technology 16274, 1:1000), anti-FOXB1 (Invitrogen PA5-28134, 1:1000), anti-SOX2 (Cell Signaling Technology 2748, 1:1000), anti-FOXC2 (Proteintech 23066-1-AP, 1:1000), anti-FOXD3 (Abcam ab64807, 1:1000), anti-FOXG1 (Abcam ab18259, 1 ug/mL), and horseradish peroxidase-linked anti-Rabbit IgG (Cell Signaling Technology 7074, 1:3000).

    Chromatin Immunoprecipitation:

    Article Title: ERRα-ETV5 axis drives PD-L1 upregulation and immune escape in gallbladder cancer.
    Article Snippet: Gallbladder cancer (GBC) is a highly aggressive malignancy with a poor response to immune checkpoint blockade (ICB), highlighting an urgent need to understand the mechanisms of immune evasion.. We identified the orphan nuclear receptor ERRα as a critical regulator of the immunosuppressive tumor microenvironment in GBC.. Mechanistically, we discovered that ERRα transcriptionally upregulates the ETS-family transcription factor ETV5, which in turn directly binds to and activates the PD-L1 (CD274) promoter, establishing a novel ERRαETV5-PD-L1 signaling axis.



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    A ChIP-seq track from NCC_CDS1_X1_C1 demonstrating CIC::DUX4 occupancy (upper gray and blue) on intron 1 of POLE . The identified peak within the intronic region of POLE on chromosome 12 containing the canonical CIC::DNA binding motif TGAATGAA and multiple variant TGAATGAG motifs. Immunoglobulin (IgG) served as control. B Schematic of the luciferase reporter construct, PGL4.10-POLE that contains the genomic sequence of POLE that is occupied by CIC::DUX4. C Relative luciferase activity in HEK293T expressing PGL4.10, PGL4.10-POLE, PGL4.10 + CIC::DUX4, and PGL4.10-POLE + CIC::DUX4 constructs. D Relative mRNA expression levels of CIC , POLE , and <t>ETV4</t> in NCC_CDS1_X1_C1 (top panels) and NCC_CDS2_C1 (bottom panels) cells transfected with siCIC (CIC::DUX4 knockdown) or scramble control (siCON). E Immunoblots of CIC, POLE and ETV4 from NCC_CDS1_X1_C1 and NCC_CDS2_C1 cells transfected with siCIC or siCON for 48 h. F Relative mRNA expression levels of CIC, POLE , and ETV4 in NCC_CDS1_X1_C1 (left panel) and NCC_CDS2_C1 (right panel) cells over-expressing CIC::DUX4-HA or empty vector (EV) control. Error bars represent standard deviation (SD); statistical significance was assessed Student’s t test. *P < 0.05 , **P < 0.01 , ***P < 0.001, ****P < 0.0001. Data represent results from three independent experiments.
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    A ChIP-seq track from NCC_CDS1_X1_C1 demonstrating CIC::DUX4 occupancy (upper gray and blue) on intron 1 of POLE . The identified peak within the intronic region of POLE on chromosome 12 containing the canonical CIC::DNA binding motif TGAATGAA and multiple variant TGAATGAG motifs. Immunoglobulin (IgG) served as control. B Schematic of the luciferase reporter construct, PGL4.10-POLE that contains the genomic sequence of POLE that is occupied by CIC::DUX4. C Relative luciferase activity in HEK293T expressing PGL4.10, PGL4.10-POLE, PGL4.10 + CIC::DUX4, and PGL4.10-POLE + CIC::DUX4 constructs. D Relative mRNA expression levels of CIC , POLE , and <t>ETV4</t> in NCC_CDS1_X1_C1 (top panels) and NCC_CDS2_C1 (bottom panels) cells transfected with siCIC (CIC::DUX4 knockdown) or scramble control (siCON). E Immunoblots of CIC, POLE and ETV4 from NCC_CDS1_X1_C1 and NCC_CDS2_C1 cells transfected with siCIC or siCON for 48 h. F Relative mRNA expression levels of CIC, POLE , and ETV4 in NCC_CDS1_X1_C1 (left panel) and NCC_CDS2_C1 (right panel) cells over-expressing CIC::DUX4-HA or empty vector (EV) control. Error bars represent standard deviation (SD); statistical significance was assessed Student’s t test. *P < 0.05 , **P < 0.01 , ***P < 0.001, ****P < 0.0001. Data represent results from three independent experiments.
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    Image Search Results


    A ChIP-seq track from NCC_CDS1_X1_C1 demonstrating CIC::DUX4 occupancy (upper gray and blue) on intron 1 of POLE . The identified peak within the intronic region of POLE on chromosome 12 containing the canonical CIC::DNA binding motif TGAATGAA and multiple variant TGAATGAG motifs. Immunoglobulin (IgG) served as control. B Schematic of the luciferase reporter construct, PGL4.10-POLE that contains the genomic sequence of POLE that is occupied by CIC::DUX4. C Relative luciferase activity in HEK293T expressing PGL4.10, PGL4.10-POLE, PGL4.10 + CIC::DUX4, and PGL4.10-POLE + CIC::DUX4 constructs. D Relative mRNA expression levels of CIC , POLE , and ETV4 in NCC_CDS1_X1_C1 (top panels) and NCC_CDS2_C1 (bottom panels) cells transfected with siCIC (CIC::DUX4 knockdown) or scramble control (siCON). E Immunoblots of CIC, POLE and ETV4 from NCC_CDS1_X1_C1 and NCC_CDS2_C1 cells transfected with siCIC or siCON for 48 h. F Relative mRNA expression levels of CIC, POLE , and ETV4 in NCC_CDS1_X1_C1 (left panel) and NCC_CDS2_C1 (right panel) cells over-expressing CIC::DUX4-HA or empty vector (EV) control. Error bars represent standard deviation (SD); statistical significance was assessed Student’s t test. *P < 0.05 , **P < 0.01 , ***P < 0.001, ****P < 0.0001. Data represent results from three independent experiments.

    Journal: Oncogene

    Article Title: The CIC::DUX4 oncoprotein maintains DNA integrity through direct regulation of the catalytic subunit of DNA polymerase epsilon (POLE)

    doi: 10.1038/s41388-025-03507-9

    Figure Lengend Snippet: A ChIP-seq track from NCC_CDS1_X1_C1 demonstrating CIC::DUX4 occupancy (upper gray and blue) on intron 1 of POLE . The identified peak within the intronic region of POLE on chromosome 12 containing the canonical CIC::DNA binding motif TGAATGAA and multiple variant TGAATGAG motifs. Immunoglobulin (IgG) served as control. B Schematic of the luciferase reporter construct, PGL4.10-POLE that contains the genomic sequence of POLE that is occupied by CIC::DUX4. C Relative luciferase activity in HEK293T expressing PGL4.10, PGL4.10-POLE, PGL4.10 + CIC::DUX4, and PGL4.10-POLE + CIC::DUX4 constructs. D Relative mRNA expression levels of CIC , POLE , and ETV4 in NCC_CDS1_X1_C1 (top panels) and NCC_CDS2_C1 (bottom panels) cells transfected with siCIC (CIC::DUX4 knockdown) or scramble control (siCON). E Immunoblots of CIC, POLE and ETV4 from NCC_CDS1_X1_C1 and NCC_CDS2_C1 cells transfected with siCIC or siCON for 48 h. F Relative mRNA expression levels of CIC, POLE , and ETV4 in NCC_CDS1_X1_C1 (left panel) and NCC_CDS2_C1 (right panel) cells over-expressing CIC::DUX4-HA or empty vector (EV) control. Error bars represent standard deviation (SD); statistical significance was assessed Student’s t test. *P < 0.05 , **P < 0.01 , ***P < 0.001, ****P < 0.0001. Data represent results from three independent experiments.

    Article Snippet: The membranes were blocked in 5% BSA in TBS-T and then probed with primary antibodies against POLE (Santa Cruz Biotechnology, sc-390785, 1:1000), p21 Waf1/Cip1 (12D1) (Cell Signaling Technology (CST) 2947, 1:500), p53 (CST, 9282, 1:1000), Anti-Pea3 (ETV4) (San Cruz, PEA3 Antibody [ ]: sc-113, 1:500), ETV5 (CST, 16274, 1:1000), DUX4 clone P4H2 (Invitrogen MA5-16147, 1:1000), Phosph-Histon H2AX (Ser139) (CST, 2577, 1;500), Capicua CIC (Abcam, ab123822, 1:500), ACTIN (CST, 4970, 1:1000), Phospho-CHK1 ser345 (133D3) (CST,2348, 1:1000) and CHK1 (CST, 2360, 1:1000), HA-tag C29F4 (CST, 3724, 1:1000).

    Techniques: ChIP-sequencing, Binding Assay, Variant Assay, Control, Luciferase, Construct, Sequencing, Activity Assay, Expressing, Transfection, Knockdown, Western Blot, Plasmid Preparation, Standard Deviation